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KMID : 0043320150380091591
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Archives of Pharmacal Research
2015 Volume.38 No. 9 p.1591 ~ p.1605
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Considerations of the chemical biology of microbial natural products provide an effective drug discovery strategy
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Choi Hyuk-Jae
Oh Dong-Chan
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Abstract
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Conventional approaches to natural product drug discovery rely mainly on random searches for bioactive compounds using bioassays. These traditional approaches do not incorporate a chemical biology perspective. Searching for bioactive molecules using a chemical and biological rationale constitutes a powerful search paradigm. Here, the authors review recent examples of the discovery of bioactive natural products based on chemical and biological interactions between hosts and symbionts, and propose this method provides a more effective means of exploring natural chemical diversity and eventually of discovering new drugs.
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KEYWORD
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Natural product, Chemical biology, Bioactive compound, Drug discovery, Insect, Marine invertebrate, Microbe, Symbiosis
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